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Case report demonstrates ultra-late recurrence of a malignant transformation in an immature teratoma, suggesting rare outcomes after treatment.
Immature teratomas of the pineal region are a subtype of non-germinomatous germ cell tumors typically associated with early recurrence. Ultra-late recurrence decades after initial treatment is exceedingly uncommon. We report an immature teratoma case in the pineal region that recurred 35 years after subtotal resection and chemoradiotherapy, showing somatic-type malignant transformation into adenoid cystic carcinoma-like adenocarcinoma.
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Ohtani et al. (2026) studied this question.
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