Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p.K298_H299insQ (c.896_897insACA)

Takumi Hirose; Kei-ichi Ishikawa; Y. Li; Genko Oyama; Taku Hatano; Nobutaka Hattori; Wado Akamatsu

doi:10.1016/j.scr.2026.103980

April 1, 2026Stem Cell ResearchOpen Access

Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p.K298_H299insQ (c.896_897insACA)

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Key Points

To generate induced pluripotent stem cell lines from a frontotemporal dementia patient with a specific MAPT mutation.
Isolated cells from a frontotemporal dementia patient with a MAPT mutation.
Established induced pluripotent stem cell lines (iPSCs) from patient cells.
Characterized iPSCs for pluripotency and differentiation potential.
Generated iPSCs showed classic characteristics of pluripotency.
iPSCs demonstrated the ability to differentiate into the three germ layers.
iPSCs maintained stable karyotypes throughout culture.

Implication

Induced pluripotent stem cell lines exhibit typical characteristics in FTD patients with MAPT mutation, suggesting potential for future therapies.

Abstract

A previously reported microtubule-associated protein tau (MAPT) mutation, p.K298_H299insQ, involving a glutamine insertion between lysine 298 and histidine 299, was identified in patients with frontotemporal dementia. We established induced pluripotent stem cell (iPSC) lines from a patient carrying this mutation. Generated iPSCs displayed typical pluripotency characteristics, differentiation potential into three germ layers, and stable karyotypes

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Cite This Study

Hirose et al. (2026) studied this question.

synapsesocial.com/papers/69cf5de95a333a821460bfb9 https://doi.org/10.1016/j.scr.2026.103980

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Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p.K298_H299insQ (c.896_897insACA)

Key Points

Implication

Abstract

Discussion

Cite This Study

Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p.K298_H299insQ (c.896_897insACA)

Key Points

Implication

Abstract

Discussion

Cite This Study

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