What question did this study set out to answer?

The aim is to identify effective analytical modeling techniques for predicting optimal tacrolimus doses in solid organ transplant recipients.

April 3, 2026PharmaceuticsOpen Access

Analytical Models to Optimize Tacrolimus Dosing in Solid Organ Transplantation: A Systematic Review

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This systematic review identifies analytical models optimizing tacrolimus dosing in transplant recipients, suggesting further research is necessary.

The aim is to identify effective analytical modeling techniques for predicting optimal tacrolimus doses in solid organ transplant recipients.
Conducted a systematic review of relevant studies
Searched multiple databases including Medline and Scopus
Focused on studies that examine analytical models for tacrolimus dosing optimization
115 studies met the inclusion criteria
Pharmacokinetic models were most commonly used, especially two-compartment models with Bayesian forecasting
Machine learning approaches showed improved predictive accuracy
Key variables for dosage included CYP3A5 genotype and hematocrit levels
Only ten studies conducted external validation, highlighting generalizability issues

Amooei et al. (2026) studied this question.

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This systematic review identifies analytical models optimizing tacrolimus dosing in transplant recipients, suggesting further research is necessary.