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This case aims to illustrate the management of papillary thyroid carcinoma with rare superior vena cava invasion and assess treatment outcomes.

April 3, 2026CureusOpen Access

Hypofractionated Radiotherapy (25 Gy/5) for Rare Superior Vena Cava Invasion by Papillary Thyroid Carcinoma: A Case Report

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Case report highlights the successful use of palliative radiotherapy for rare SVC invasion in thyroid cancer.

This case aims to illustrate the management of papillary thyroid carcinoma with rare superior vena cava invasion and assess treatment outcomes.
Presented a case of an 84-year-old woman with pT4aN1 papillary thyroid carcinoma.
Initial management included thyroidectomy, I-131 therapy, neck dissection, and external beam radiotherapy.
Administered a short course of palliative hypofractionated radiotherapy (25 Gy in 5 fractions).
Evaluated radiographic responses over the following year.
Palliative external beam radiotherapy resulted in significant radiographic improvement.
No hemorrhagic complications occurred during treatment.
Indicated the potential for moderately hypofractionated radiotherapy in managing rare cases of SVC invasion.

Jin et al. (2026) studied this question.

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