This umbrella review examines noncardiometabolic outcomes of GLP-1 receptor agonists, suggesting implications for safety and health associations.
In this umbrella review of meta-analyses, evidence for most noncardiometabolic outcomes associated with GLP-1 RAs was of lower certainty. Potential safety signals were observed for gastrointestinal AEs, while suggested protective associations with respiratory diseases and serious infections require further confirmation.
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Yang et al. (2026) studied this question.
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