Formal (4+3) cycloadditions create polycyclic compounds using epoxy allylsilanes as dienophiles, suggesting new synthetic pathways.
Methylenated cycloheptanoids are synthesized by formal (4+3) cycloadditions of dienes with epoxy allylsilanes as dienophiles in the presence of catalytic amounts of TESOTf. Intermolecular and intramolecular (4+3) cycloadditions with dienes including furans, cyclopentadiene, pyrroles, thiophenes, and benzenes proceeded to provide polycyclic adducts in moderate to good yields.
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Teo et al. (2026) studied this question.
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