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Prospective cohort study shows that perioperative stress phenotypes predict immune recovery failure in colorectal cancer, indicating future risk stratification opportunities.
Perioperative systemic stress phenotypes reflecting sustained psychoneuroendocrine-immune dysregulation are associated with immune recovery failure, molecular residual disease, and adverse long-term outcomes following a major surgery. Quantifying dynamic stress-related biological responses may provide a biologically grounded framework for understanding how acute psychoneuroendocrine stress translates into persistent immune vulnerability and may inform future risk stratification research in perioperative oncology.
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Pan et al. (2026) studied this question.
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