Functional Neuroimaging Biomarkers of Impaired Neurocognition After Proton Beam Radiotherapy for Brain Tumors in Pediatric Patients: A Prospective Trial

Key Points

• The research examines the effects of proton beam radiotherapy on neurocognition in pediatric patients.
• Conducted a prospective trial
• Compared pediatric patients after proton beam radiotherapy to healthy controls
• Analyzed resting state networks related to neurocognitive control
• Patients showed significant disruption in resting state networks, particularly between the salience network and default mode network.
• Dose-dependent impairment in neurocognition and quality of life was observed.