Demonstrates enhanced antitumor effects in triple-negative breast cancer using novel gold nanoparticles and immunotherapy, suggesting a new treatment strategy.
Key Points
The aim is to enhance the effectiveness of treatments for triple-negative breast cancer by using solamargin-functionalized gold nanoparticles.
Engineered Au@PEG-SM nanoconjugate for targeted delivery.
Utilized vascular endothelial cell models and STING-specific inhibitors.
Conducted systemic immune profiling and utilized bilateral tumor models.
Au@PEG-SM combined with photothermal therapy improves therapeutic efficacy beyond traditional methods.
Synergistic treatment activates the cGAS-STING pathway, promoting significant cytokine release.
The combination therapy increases NK and CD8 + T cell infiltration while reducing immunosuppressive cells.