A Neutral BODIPY Molecular Rotor Photosensitizer for Mitochondrial Targeting

Surendra Kumar; Anjani Kumar; Durgendra Yadav; Sathya  prakash Kumarasamy; Vinay Sharma; Roop Shikha Singh

doi:10.1039/d5an01314c

January 1, 2026The Analyst

A Neutral BODIPY Molecular Rotor Photosensitizer for Mitochondrial Targeting

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Key Points

The study aims to explore the design and synthesis of neutral sulfone–BODIPY molecular rotors for effective mitochondrial targeting.
Designed and synthesized two neutral sulfone–BODIPY-based molecular rotors (SB1 and SB2).
Integrated viscosity-responsive fluorescence with intersystem crossing (ISC).
Analyzed ROS generation capabilities in response to viscosity changes.
Both SB1 and SB2 exhibited strong fluorescence upon increasing viscosity.
Demonstrated effective ROS generation via ISC in mitochondria-targeted environments.
Showed potential applications in therapeutic settings due to enhanced targeting and fluorescence properties.

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Implication

Novel sulfone–BODIPY molecular rotors enhance ROS generation in mitochondrial environments, indicating potential for therapeutic uses.

Abstract

Herein, two novel neutral sulfone–BODIPY-based molecular rotors (SB1 and SB2) have been designed and synthesized, integrating viscosity-responsive turn-on fluorescence with ISC-driven ROS generation. The sulfone group acted as a strong...

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Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e3d5a333a821460c70e https://doi.org/10.1039/d5an01314c

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A Neutral BODIPY Molecular Rotor Photosensitizer for Mitochondrial Targeting

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Abstract

Discussion

Cite This Study

A Neutral BODIPY Molecular Rotor Photosensitizer for Mitochondrial Targeting

Key Points

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Implication

Abstract

Discussion

Cite This Study

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