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April 3, 2026Organic Chemistry Frontiers3 citations

Redox-Neutral Assembly of Diheteroarylalkanes via Transient Directing Group-Enabled C-H Methylenation

XWXuemeng WangLXLiqing XuKMKexin Ma

Key Points

  • The aim is to develop a transition-metal-free method for the regioselective C(sp²)–H methylenation of quinolines and indoles.
  • Utilized Eschenmoser’s salt for C-H methylenation
  • Performed homocoupling of quinolines
  • Conducted cross-coupling between quinolines and indoles
  • Focused on reaction efficiency and regioselectivity
  • Achieved direct access to two classes of diheteroarylalkanes
  • Demonstrated high regioselectivity in product formation
  • Eliminated the need for transition metals in the process

Abstract

We report transition-metal-free homocoupling of quinolines and cross-coupling between quinolines and indoles via regioselective C(sp²)–H methylenation using Eschenmoser’s salt, providing direct access to two classes of diheteroarylalkanes. Mechanistic studies unveil...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e3d5a333a821460c7b2https://doi.org/10.1039/d6qo00215c
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