Ameliorative Effects of Red-Fleshed Apple Flavonoid Extracts (RAFEs) on High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice

Yun Chen; Yaqi Dong; Zhaozheng Fan; Shenghui Jiang; Ya Wu; Chengkun Wang; Tongyao Zhu; Zhongkang Wang; Shaoxia Guo; Yugang Zhang; Xiao Liang

doi:10.1039/d5fo05405b

January 1, 2026Food & Function

Ameliorative Effects of Red-Fleshed Apple Flavonoid Extracts (RAFEs) on High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice

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Key Points

To assess the effects of red-fleshed apple flavonoid extracts (RAFEs) on metabolic dysfunction and liver disease induced by a high-fat diet in mice.
Administered RAFEs to mice on a high-fat diet
Monitored liver health and metabolic markers
Conducted biochemical analyses to evaluate outcomes
RAFEs significantly reduced liver fat accumulation in treated mice
Improved metabolic markers associated with liver dysfunction
Highlighted the potential of dietary flavonoids in liver health

Implication

Demonstrates the impact of apple flavonoids on liver disease in mice, suggesting potential dietary interventions for metabolic health.

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, yet effective therapeutic options remain limited. Red-fleshed apples are rich in dietary flavonoids, but their chemical...

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e505a333a821460c885 https://doi.org/10.1039/d5fo05405b

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Ameliorative Effects of Red-Fleshed Apple Flavonoid Extracts (RAFEs) on High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

Ameliorative Effects of Red-Fleshed Apple Flavonoid Extracts (RAFEs) on High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

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