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March 1, 2026Journal of Oral and Maxillofacial SurgeryOpen Access

The effectiveness of decompression in ameloblastoma treatment: A systematic review and meta-analysis

Sahand Samieirad Abdolvahab Moradi Ali Mirzaei Wagner Calais R. García-Miralles Grávalos Ricardo Grillo

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Key Points

This study evaluates the effectiveness of decompression treatment in managing ameloblastoma and its implications for recurrence rates.
Systematic search across multiple databases following PRISMA guidelines
Meta-analysis of proportions using a random-effects model in RStudio
Assessment of heterogeneity using I and Tau statistics
Analysis of data from nine studies including 555 ameloblastomas
Decompression yielded a mean size reduction of 55.3% in ameloblastomas
Overall recurrence rate was 3.8 per 100 person-years, with unicystic at 2.1 and multicystic at 8.9 per 100 person-years
Longer decompression duration (>12 months) significantly reduced the recurrence hazard by 48%

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Implication

Systematic review reports decompression reduces ameloblastoma size but recurrence risks vary by subtype, suggesting tailored treatment.

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Cite This Study

Samieirad et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e995a333a821460d060 https://doi.org/10.1016/j.joms.2026.03.015

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1ANALYSIS OF SURGICAL APPROACHES FOR THE TREATMENT OF AMELOBLASTOMA: AN INTEGRATIVE REVIEW2024 · 1 citations
2A three-dimensional quantitative assessment on bony growth and symmetrical recovery of mandible after decompression for unicystic ameloblastoma2024 · 1 citations
3Conservative Versus Radical Treatment of Ameloblastoma: A 14-Year Study in Kedah, Malaysia2024 · 1 citations
4Mandibular Ameloblastoma: Frequency and Risk Factors for Recurrence Within a North African Population2025
5Curettage combined with decompression for the treatment of ameloblastoma in children: report of two cases2024 · 11 citations

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Three-dimensional changes in mandibular jaw cysts following decompression surgery: a retrospective cohort study.2026
Clinicopathological profile and recurrence of ameloblastoma:11-year retrospective study in Indonesian national referral Hospital2026
Decompression in the Management of Large Cystic Lesions Associated With Mixed Dentition Phase: 2 Case Reports2025

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