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April 3, 2026Blood Advances3 citationsOpen Access

American Society of Hematology 2026 Guidelines for the Diagnosis and Management of Severe Acquired Aplastic Anemia

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PSPhillip ScheinbergDODebra A O'NealABAna Lisa Basquiera

Key Points

  • This research outlines the best practices for diagnosing and managing severe acquired aplastic anemia.
  • Developed guidelines through expert panel recommendations
  • Prioritized hematopoietic cell transplantation
  • Recommended use of eltrombopag with immunosuppressive regimens
  • Suggested antibiotic and antifungal prophylaxis for neutropenic patients
  • Hematopoietic cell transplantation is favored for younger individuals with compatible donors
  • Eltrombopag is recommended to enhance immunosuppressive therapy
  • Prophylaxis measures are indicated to reduce infections in neutropenic patients

Abstract

Recommendations emphasize prioritizing hematopoietic cell transplantation for younger individuals with an available matched sibling or unrelated donor and as a second-line option following failure of immunosuppressive therapy. The panel also recommended adding eltrombopag to immunosuppressive regimens and using antibiotic and antifungal prophylaxis in neutropenic patients.

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Cite This Study

Scheinberg et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ea85a333a821460d3a1https://doi.org/10.1182/bloodadvances.2025019051
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