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April 3, 2026Food & Function0 citations

Curcumin attenuates nanoparticle-induced renal injury via the PI3K/AKT signaling pathway

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HRHuiyuan RuiXXXinran xuSLShuhui Liu

Key Points

  • The research aims to investigate the protective effects of curcumin against renal injury induced by polystyrene nanoparticles through the PI3K/AKT signaling pathway.
  • Utilized network pharmacology to identify potential pathways of curcumin
  • Conducted in vitro experiments on kidney cells
  • Carried out in vivo studies on animal models of kidney injury
  • Curcumin significantly reduced markers of renal injury in both in vitro and in vivo models
  • Activation of the PI3K/AKT signaling pathway was observed
  • Polystyrene nanoparticle exposure led to elevated kidney damage markers, which curcumin helped decrease

Abstract

Exposure to polystyrene nanoplastics (PS-NPs) endangers human health, so exploring curcumin (Cur)'s nephroprotective effects against PS-NPs-induced injury is crucial. This research integrated network pharmacology with in vitro and in vivo...

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Cite This Study

Rui et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ebc5a333a821460d3e4https://doi.org/10.1039/d6fo00638h
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