Curcumin attenuates nanoparticle-induced renal injury via the PI3K/AKT signaling pathway

Q: What does this research mean for the field?

Curcumin protects against polystyrene nanoplastic-induced renal injury by modulating the PI3K/AKT signaling pathway. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Huiyuan Rui; Xinran xu; Shuhui Liu; Xueli Gao; Xiaowen Jiang; Wenhui Yu

doi:10.1039/d6fo00638h

January 1, 2026Food & Function

Curcumin attenuates nanoparticle-induced renal injury via the PI3K/AKT signaling pathway

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Key Points

The research aims to investigate the protective effects of curcumin against renal injury induced by polystyrene nanoparticles through the PI3K/AKT signaling pathway.
Utilized network pharmacology to identify potential pathways of curcumin
Conducted in vitro experiments on kidney cells
Carried out in vivo studies on animal models of kidney injury
Curcumin significantly reduced markers of renal injury in both in vitro and in vivo models
Activation of the PI3K/AKT signaling pathway was observed
Polystyrene nanoparticle exposure led to elevated kidney damage markers, which curcumin helped decrease

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Implication

Research shows curcumin mitigates kidney injury caused by polystyrene nanoparticles, suggesting potential therapeutic benefits.

Abstract

Exposure to polystyrene nanoplastics (PS-NPs) endangers human health, so exploring curcumin (Cur)'s nephroprotective effects against PS-NPs-induced injury is crucial. This research integrated network pharmacology with in vitro and in vivo...

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Rui et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ebc5a333a821460d3e4 https://doi.org/10.1039/d6fo00638h

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Curcumin attenuates nanoparticle-induced renal injury via the PI3K/AKT signaling pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

Curcumin attenuates nanoparticle-induced renal injury via the PI3K/AKT signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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