Comparison of biomechanical assessment between upright and supine inspiratory-expiratory area-detector CT in progressive pulmonary fibrosis

Yoshiharu Ohno; Kota Aoyagi; Yoshiyuki Ozawa; Masahiko Nomura; Hirona Kimata; Yuya Ito; Kenji Fujii; Takahiro Ueda; Junichiro Araoka; Naruomi Akino; Takeshi Yoshikawa; Daisuke Takenaka; M. Endo; Yasushi Hoshikawa; Hidekata Yasuoka; Tomoya Horiguchi; Yasuhiro Goto; Naozumi Hashimoto; Kazuyoshi Imaizumi

doi:10.1186/s41747-026-00698-y

Key Points

To compare biomechanical assessments and correlations of disease severity between upright and supine area-detector CT in patients with progressive pulmonary fibrosis.
Matched patients with progressive pulmonary fibrosis were analyzed.
Biomechanical assessments were conducted using inspiratory-expiratory upright and supine area-detector CT.
Clinical parameters and warp-field magnitude were evaluated for correlations.
Better correlations observed between clinical parameters and upright area-detector CT.
Warp-field magnitude correlated more strongly with disease severity compared to the logarithm of the Jacobian determinant.

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Implication

Matched assessments reveal superior correlations between upright CT imagery and disease severity evaluations in pulmonary fibrosis.

Abstract

Matched progressive pulmonary fibrosis patients compared functional loss and disease severity evaluations between inspiratory-expiratory upright and supine area-detector CT. Clinical parameters demonstrated better correlations with upright than with supine inspiratory-expiratory area-detector CT. Warp-field magnitude showed better correlations with disease severities than the logarithm of the Jacobian determinant on each area-detector CT.

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Ohno et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ebd5a333a821460d4d1 https://doi.org/10.1186/s41747-026-00698-y

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Comparison of biomechanical assessment between upright and supine inspiratory-expiratory area-detector CT in progressive pulmonary fibrosis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Comparison of biomechanical assessment between upright and supine inspiratory-expiratory area-detector CT in progressive pulmonary fibrosis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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