Palladium-Catalyzed Defluorinative Coupling of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: Direct Access to Functionalized α-Fluoroenones

Chunming Chen; Huixuan Zhu; Zhengli Luo; Jinhui Hu; Zhuang Xiong; Fucheng Zhou; Jiaqiang Wu

doi:10.1039/d6ob00246c

January 1, 2025Organic & Biomolecular Chemistry

Palladium-Catalyzed Defluorinative Coupling of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: Direct Access to Functionalized α-Fluoroenones

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Key Points

This research aims to develop a method for synthesizing α-fluoroenones from indoles and difluoro-unsaturated ketones.
Utilized palladium as a catalyst for the coupling process.
Combined indoles with α,α-difluoro-β,γ-unsaturated ketones.
Conducted reactions under mild conditions for improved yields.
Achieved moderate to excellent yields of (Z)-α-fluoroenones.
Generated a diverse range of functionalized compounds.

Implication

Palladium-catalyzed coupling produces functionalized α-fluoroenones, suggesting a new synthetic route.

Abstract

A palladium-catalyzed defluorinative coupling of indoles with α,α-difluoro-β,γ-unsaturated ketones is reported.This method provides direct access to a diverse range of functionalized (Z)-α-fluoroenones in moderate to excellent yields under mild conditions....

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/69cf5ebd5a333a821460d554 https://doi.org/10.1039/d6ob00246c

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Palladium-Catalyzed Defluorinative Coupling of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: Direct Access to Functionalized α-Fluoroenones

Key Points

Implication

Abstract

Discussion

Cite This Study

Palladium-Catalyzed Defluorinative Coupling of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: Direct Access to Functionalized α-Fluoroenones

Key Points

Implication

Abstract

Discussion

Cite This Study

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