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April 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Efficacy of Micronized Progesterone in Preventing Placental Insufficiency

Efficacy of micronized progesterone-based preparations used to prevent placental insufficiency: an experimental study

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Authors

GBGalina A. BatishchevaYZYana ZolotukhinaVSV. V. Shishkina

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Overview

Experimental study demonstrates that micronized progesterone improves outcomes in placental insufficiency, indicating its potential benefits.

Key Points

  • To evaluate the efficacy of micronized progesterone in preventing placental insufficiency and its impact on offspring development.
  • Formed four observation groups with intact and pregnant rats
  • Administered micronized progesterone at dosages of 20 mg/day and 40 mg/day
  • Conducted histological and immunohistochemical analyses of the placenta
  • Analyzed anthropometric and physical development parameters of the offspring
  • Miscarriage rate of 16% in pregnant rats without MP treatment
  • Pregnancy and development parameters in EG1 within normal range
  • EG2 showed normal parameters but one rat experienced convulsions during birth
  • Reduced inflammation noted in placentas of rats treated with MP compared to control group

Cite This Study

Batishcheva et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ecb5a333a821460d6e7https://doi.org/10.18413/rrpharmacology.12.1030
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