Key result
Human PP13 reduced blood pressure and caused significant vasodilatation in isolated arteries of gravid and non-gravid rodents, with prolonged exposure increasing uteroplacental artery angiogenesis.
Why the study?
Does placental protein 13 (PP13) reduce blood pressure and improve uteroplacental blood flow in rodents?
Does placental protein 13 (PP13) reduce blood pressure and improve uteroplacental blood flow in rodents?
PP13 induces vasodilatation and uteroplacental artery remodeling in rodents, suggesting a potential physiological role in maternal vascular adaptation to pregnancy.
PP13 effects on rodent vascular function remain hypothesis-generating; leaves open clinical translation in preeclampsia.
OBJECTIVES: Here, we performed a pathophysiological examination of the vascular function of rodent in the presence of placental protein 13 (PP13) and its implication to regulate the development of preeclampsia. METHODS: Single i.v. injection and prolonged in vivo exposure to PP13 via osmotic pumps were performed in gravid and non-gravid rats to examine the influence of PP13 on blood pressure and heart rate in animals. The effect of PP13 was also examined in isolated uterine and mesenteric arteries, along with the examination of placental blood supply. RESULTS: Human PP13 has a major impact on the maternal cardiovascular system of rodents by reducing blood pressure, either at single or prolonged exposure, and causing significant vasodilatation in isolated arteries. Prolonged exposure was followed by increased elaboration and angiogenesis of the uteroplacental arteries supplying the placenta. CONCLUSION: This is the first study describing effects of PP13 on vasodilatation and uterine artery remodeling. The results imply that PP13 may have a physiological role in improving uteroplacental blood flow. The findings of this study make it tempting to speculate that keeping PP13 levels within a certain 'therapeutic window' during pregnancy may facilitate proper adaptation of the maternal vasculature to pregnancy.
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Gizurarson et al. (2013) studied Preeclampsia (animal model). Placental protein 13 (PP13) was evaluated on Blood pressure, heart rate, vasodilatation, and placental blood supply. Human PP13 reduced blood pressure and caused significant vasodilatation in isolated arteries of gravid and non-gravid rodents, with prolonged exposure increasing uteroplacental artery angiogenesis.
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