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April 3, 2026Angewandte Chemie International Edition

Inside Front Cover: A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

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Authors

WZWanying ZhuYZYufan ZhangHYHanwen Yu

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Overview

Research article demonstrates a new nanosensor that monitors acetylcholine release in neurons, indicating advances in neurotransmitter analysis.

Key Points

  • The study aims to develop a nanosensor to monitor acetylcholine dynamics in living neurons with high precision.
  • Introduced Ti3C2Tx MXene/enzyme-functionalized nanosensor platform.
  • Achieved high spatiotemporal resolution for neurotransmitter analysis.
  • Inserted the nanosensor into living neurons to monitor single-vesicle dynamics.
  • Successfully monitored single-vesicle acetylcholine storage.
  • Tracked exocytosis dynamics in real time.
  • Demonstrated breakthroughs in technical barriers for neurotransmitter analysis.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ecb5a333a821460d734https://doi.org/10.1002/anie.2026-m2603023100
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