What question did this study set out to answer?

To evaluate the feasibility of using cell-free DNA in culture media for detecting chromosomal abnormalities in preimplantation embryos and assess its impact on clinical outcomes.

April 3, 2026GenesOpen Access

Can Cell-Free DNA in the Culture Medium Predict the Chromosomal Constitution of Preimplantation Embryos? Final Results from a Multicenter Study with 2539 Blastocysts

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Authors

LNLuis Navarro-SánchezIgenomix DSDenny SakkasBoston IVF NFNilo Frantz

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Implication

Multicenter study shows non-invasive PGT-A predicts embryo aneuploidy in blastocysts, indicating its clinical utility.

Key Points

To evaluate the feasibility of using cell-free DNA in culture media for detecting chromosomal abnormalities in preimplantation embryos and assess its impact on clinical outcomes.
Multicenter, international study involving 716 patients and 2539 blastocysts.
Embryos were cultured per specific non-invasive PGT-A protocols.
Spent blastocyst medium and trophectoderm biopsies were obtained and analyzed for concordance.
Clinical outcomes from embryo transfers were recorded and analyzed in relation to aneuploidy results.
Concordance rate between spent blastocyst medium and trophectoderm was 79.1%, increasing to 87.0% when including inner cell mass comparisons.
A lower miscarriage rate was observed in concordant euploid blastocysts (13.0%) compared to those with euploid trophectoderm and aneuploid spent medium (22.2%).
The adapted embryo culture protocols did not negatively impact blastocyst quality.

Cite This Study

Navarro-Sánchez et al. (2026) studied this question.

synapsesocial.com/papers/69cf5f005a333a821460dc47 https://doi.org/10.3390/genes17040416

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Can Cell-Free DNA in the Culture Medium Predict the Chromosomal Constitution of Preimplantation Embryos? Final Results from a Multicenter Study with 2539 Blastocysts

Discussion

Member takes

Implication

Key Points

Cite This Study

Can Cell-Free DNA in the Culture Medium Predict the Chromosomal Constitution of Preimplantation Embryos? Final Results from a Multicenter Study with 2539 Blastocysts

Discussion

Member takes

Implication

Key Points

Cite This Study

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