Key result
Surgical PVR shows superior mid-term cost-effectiveness over TPVR in young adults with rTOF.
Why the study?
Does surgical pulmonary valve replacement improve mid-term cost-effectiveness compared to transcatheter pulmonary valve replacement in young adults with repaired tetralogy of Fallot and pulmonary valve regurgitation?
Does surgical pulmonary valve replacement improve mid-term cost-effectiveness compared to transcatheter pulmonary valve replacement in young adults with repaired tetralogy of Fallot and pulmonary valve regurgitation?
Clinical decision modeling suggests surgical pulmonary valve replacement is more cost-effective in the mid-term than transcatheter replacement for young adults with repaired tetralogy of Fallot.
May favor surgical over transcatheter PVR in young repaired ToF adults; extends decision modeling but leaves open real-world validation.
Comprehensive modelling of diverse outcomes showed that surgical pulmonary valve replacement had superior mid-term cost-effectiveness outcomes compared to transcatheter pulmonary valve replacement for young adults with repaired tetralogy of Fallot and pulmonary valve regurgitation. Sensitivity analysis found that the prevalence of post-transcatheter pulmonary valve replacement endocarditis and post-transcatheter pulmonary valve replacement surgical reintervention were influential outcomes for centres to consider when choosing between these strategies.
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Zhu et al. (2026) studied this question. Surgical pulmonary valve replacement demonstrated superior mid-term cost-effectiveness compared to transcatheter replacement in young adults with repaired tetralogy of Fallot.
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