Research reveals that umbilical cord blood stem cells alleviate autism-like behaviors in mice, suggesting a novel therapy for autism spectrum disorder.
These findings suggest that hUC-MSCs may exert neuroprotective effects by modulating the IGF-1/Akt signaling pathway, promoting neuronal development, reducing neuroinflammation, and inhibiting apoptosis, ultimately alleviating core ASD-like symptoms. The therapeutic benefits may stem from paracrine factors secreted by hUC-MSCs or their ability to regulate gene expression linked to neuronal development. Our study provides new insights into ASD pathogenesis and highlights the potential of hUC-MSCs as a novel stem cell-based therapy for ASD.
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Tian et al. (2026) studied this question.
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