Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas

Enrico Berrino; Sara E. Bellomo; Maria Costanza Aquilano; Marta Falcinelli; Anita Chesta; Emanuele Valtorta; Daniela Zampieri; Gianluca Mauri; Giuseppe Sala; Silvia Marsoni; A. Bardelli; Andrea Sartore-Bianchi; Salvatore Siena; Anna Sapino; Emanuela Bonoldi; Fabrizio d’Adda di Fagagna; Caterina Marchiò

doi:10.1093/oncolo/oyag116

March 26, 2026The OncologistOpen Access

Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas

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Key Points

The research aims to explore the relationship between γH2AX phosphorylation and the immune microenvironment in colorectal carcinomas.
Analysis of γH2AX expression levels in colorectal carcinoma samples
Assessment of MMR proficiency
Examination of histopathological features
Evaluation of immune microenvironment characteristics
Elevated γH2AX corresponds with proficient MMR status in colorectal carcinomas
Higher levels of γH2AX are linked to aggressive tumor features
Distinctive immune-active environments are associated with altered γH2AX expression

Implication

Elevated γH2AX expression correlates with immune features in colorectal carcinomas, suggesting its prognostic value.

Abstract

Elevated γH2AX expression correlates with MMR proficiency, aggressive histopathologic features, and a distinctive immune-active microenvironment in CRC. These findings may support γH2AX as a marker of immune-modulated CRC subgroups with potential prognostic and therapeutic relevance.

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Cite This Study

Berrino et al. (2026) studied this question.

synapsesocial.com/papers/69cf5f225a333a821460e140 https://doi.org/10.1093/oncolo/oyag116

View Full Paper

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Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas

Key Points

Implication

Abstract

Discussion

Cite This Study

Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas

Key Points

Implication

Abstract

Discussion

Cite This Study

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