Key result
Watchful waiting with combined antiplatelet and anticoagulant therapy resolves massive coronary thrombus during BEP chemotherapy.
Why the study?
BEP chemotherapy is associated with acute coronary syndromes involving vasospasm and thrombus without atherosclerosis, suggesting conservative management may be beneficial.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
A watchful waiting strategy with combined antiplatelet and anticoagulant therapy may be a safe and effective alternative to percutaneous coronary intervention for hemodynamically stable patients with BEP chemotherapy-induced coronary thrombosis.
The relationship between the combination of bleomycin-etoposide-cisplatin, a chemotherapeutic treatment option used in testicular carcinomas, and acute thrombotic events has been previously described. Acute coronary syndromes associated with this treatment have been frequently reported. The differences in the underlying mechanisms that lead to coronary events suggest that the treatment options may vary in these situations. The decision regarding the right treatment option for the patient sometimes emerges after a relatively long process that requires patience. In this event, which occurs without atherosclerosis and involves vasospasm and thrombus formation, a conservative approach may be beneficial. A 42-year-old individual diagnosed with testicular cancer who did not have any cardiac risk factors was diagnosed with acute coronary syndrome. Since no atherosclerotic background is observed on coronary angiography, coronary intervention is postponed. In this case, the management of the patient will be discussed with a focus on medical treatment without any coronary intervention.
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Çakan et al. (2026) conducted a case report in Coronary thrombosis secondary to BEP chemotherapy (n=1). Watchful waiting strategy with medical therapy (antiplatelets and anticoagulants) was evaluated on Resolution of coronary thrombus. A watchful waiting strategy with combined antiplatelet and anticoagulant therapy successfully resolved a massive coronary thrombus in a patient receiving BEP chemotherapy for testicular cancer.
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