Clinical characteristics, associated comorbidities, and treatment approaches in pyoderma gangrenosum: a single-center retrospective analysis

MethodsWe accessed the hospital database to review the records of 44 patients that were diagnosed with PG and treated at our facility from 1995 to 2019.Demographic data, clinical characteristics (localization, clinical variants, and number of lesions), associated systemic diseases, and treatment modalities were analyzed.The initial workup included erythrocyte sedimentation rate; C-reactive protein; blood cell count; liver and renal functional testing; quantitative serum immunoglobulin (Ig)A, IgM, and IgG levels; serum electrophoresis; urinalysis; cytoplasmic and perinuclear anti-neutrophil cytoplasmic antibodies, antinuclear antibodies; antiphospholipid antibodies; extractable nuclear antigen screening; cryoglobulins; and immune complexes.Enzyme-linked immunosorbent assay (ELISA) for HIV 1/2, as well as hepatitis B and C, and syphilis serologies were performed.Additional procedures included colonoscopy in patients with suspicion of IBD, bone marrow biopsy in patients with signs of hematological disorders, and color Doppler ultrasonography to exclude vascular etiology in cases with ulcerative lesions.Diagnoses were based