Effect of systemic inflammation response index on reduced renal function in the population of Northeast China: A cross-sectional study

Objective: Recent studies have recognized systemic inflammatory response index (SIRI) as a novel marker of inflammation. Inflammation has been demonstrated to contribute to the development and progression of chronic kidney disease through complex mechanisms. Our study was conducted with the objective of evaluating the relationship between SIRI and reduced renal function, investigating the potential effectiveness of SIRI in optimizing the risk stratification of reduced renal function. Methods: This cross-sectional study utilized data from the Northeast China Rural Cardiovascular Health Study. A total of 8095 participants (mean age 54.13 years; 45.6% male) from Northeast China (Liaoning Province) were included between January 2012 and August 2013. The SIRI was calculated using the counts of monocyte, neutrophil, and lymphocyte. Results: The prevalence of reduced renal function was found to be 2.63%. After adjusting for all confounders, an increase of one standard deviation in SIRI was found to cause an additional 43.2% risk of reduced renal function. When SIRI was divided into quartiles, the top quartile was 1.915 times more likely to have reduced renal function than the bottom quartile. Furthermore, smooth curve fitting and subgroup analyses corroborated that this relationship was linear and robust, respectively. Finally, after SIRI was added to an established risk model, the results of receiver operating characteristic analysis and reclassification analysis were consistent, indicating a significant improvement in the capacity to stratify the risk of reduced renal function. Conclusion: Our study revealed an independent correlation between SIRI and the prevalence of reduced renal function. Our results also suggest the potential effectiveness of SIRI in optimizing the risk stratification of reduced renal function in a general population.