Why the study?
Does right ventricular functional reserve during exercise differ between patients with SSc-PAH and IPAH?
Does right ventricular functional reserve during exercise differ between patients with SSc-PAH and IPAH?
RV dilation during exercise can predict adverse ventricular-vascular coupling in PAH patients, with SSc-PAH patients demonstrating worse RV contractile reserve than those with IPAH.
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May identify higher-risk SSc-PAH during exercise; hypothesis-generating for subtype-specific risk stratification.
Hsu et al. (2016) studied this question.
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