Clinical trial reveals sequential treatment options for treatment-resistant depression, providing practical guidance for managing initial therapy failure.
The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut "winner", it does provide guidance on how to start therapy and how to proceed if initial treatment fails.
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Gaynes et al. (2008) studied this question.
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