Prospective multicenter study demonstrates persistent symptoms and functional disability in treatment-resistant depression receiving standard care, highlighting the need for novel therapies.
Despite the wide range of treatment options available for depression, the response rates, remission rates, and quality-of-life results in this study show that most patients with a substantial degree of treatment resistance continue to have significant symptomatology and functional disability when receiving TAU.
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Dünner et al. (2006) studied this question.
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