Prospective, Long-Term, Multicenter Study of the Naturalistic Outcomes of Patients With Treatment-Resistant Depression

Key Points

• To evaluate the long-term naturalistic outcomes, including response rates, remission rates, and quality of life, in patients with treatment-resistant depression receiving treatment as usual.
• Prospective, long-term, multicenter naturalistic observational study design.
• Tracked clinical response, remission status, functional impairment, and quality-of-life metrics among patients with treatment-resistant depression receiving treatment as usual (TAU).
• Most patients with substantial treatment resistance continued to suffer from significant depressive symptomatology and functional disability despite ongoing treatment as usual.
• Clinical response, remission rates, and quality-of-life outcomes remained poor across available standard-of-care options.