Why the study?
Women face a disproportionate burden of stroke mortality and disability, with biologic sex and sociocultural gender contributing to differences in stroke risk factors, assessment, treatment, and outcomes.
Design
Review
Emphasizes sex- and gender-informed stroke strategies now; leaves open targeted trials to reduce women's excess burden.
Women face a disproportionate burden of stroke mortality and disability. Biologic sex and sociocultural gender both contribute to differences in stroke risk factors, assessment, treatment, and outcomes. There are substantial differences in the strength of association of stroke risk factors, as well as female-specific risk factors. Moreover, there are differences in presentation, response to treatment, and stroke outcomes in women. This review outlines current knowledge of impact of sex and gender on stroke, as well as delineates research gaps and areas for future inquiry.
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Rexrode et al. (2022) studied this question.
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