Association between polymorphisms in microRNA biosynthesis genes and acute lymphoblastic leukemia susceptibility in Chinese children and adolescents

Key Points

• The central aim is to investigate the relationship between specific genetic variations and the risk of developing acute lymphoblastic leukemia in Chinese youth.
• Analysis of polymorphisms in microRNA biosynthesis genes.
• Focus on children and adolescents with acute lymphoblastic leukemia.
• Statistical evaluation of genetic associations.
• Identified significant associations with specific SNPs in genes DROSHA, DGCR8, and AGO1.
• Suggested possible interactions between these identified SNPs.
• Increased susceptibility to acute lymphoblastic leukemia linked to certain genetic variants.