Association between polymorphisms in microRNA biosynthesis genes and acute lymphoblastic leukemia susceptibility in Chinese children and adolescents

Q: What does this research mean for the field?

Polymorphisms in microRNA biosynthesis genes, specifically DROSHA rs10035440, DGCR8 rs1640299, AGO1 rs636832, and rs139919, as well as their potential interactions, are associated with acute lymphoblastic leukemia susceptibility in Chinese children and adolescents. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Xiaoqing Cao; Lei Wang; Yurou Kang; Ping Tai; Nayun Chen; Yang Liu; Y F Yang; Daihua Fang; Bangshun He

doi:10.1080/17410541.2026.2653871

April 2, 2026Personalized Medicine

Association between polymorphisms in microRNA biosynthesis genes and acute lymphoblastic leukemia susceptibility in Chinese children and adolescents

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Key Points

The central aim is to investigate the relationship between specific genetic variations and the risk of developing acute lymphoblastic leukemia in Chinese youth.
Analysis of polymorphisms in microRNA biosynthesis genes.
Focus on children and adolescents with acute lymphoblastic leukemia.
Statistical evaluation of genetic associations.
Identified significant associations with specific SNPs in genes DROSHA, DGCR8, and AGO1.
Suggested possible interactions between these identified SNPs.
Increased susceptibility to acute lymphoblastic leukemia linked to certain genetic variants.

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Implication

Identifies genetic factors associated with leukemia susceptibility in children, suggesting new insights for prevention.

Abstract

This study suggests that DROSHA rs10035440, DGCR8 rs1640299, AGO1 rs636832, and rs139919 May be associated with ALL susceptibility in Chinese children and adolescents. It also suggests that potential interactions may exist between these SNPs.

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Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/69d0ae68659487ece0fa4555 https://doi.org/10.1080/17410541.2026.2653871

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Association between polymorphisms in microRNA biosynthesis genes and acute lymphoblastic leukemia susceptibility in Chinese children and adolescents

Key Points

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Implication

Abstract

Discussion

Cite This Study

Association between polymorphisms in microRNA biosynthesis genes and acute lymphoblastic leukemia susceptibility in Chinese children and adolescents

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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