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This research evaluates the tropism and replication of cattle influenza A(H5N1) in human tissues, indicating potential health risks.
In 2024, influenza A(H5N1) genotype B3.13 viruses emerged from cattle and caused mild spillover infections in humans. Using human bronchus and lung tissue, we evaluated tropism, replication, and pathogenesis of 2 cattle influenza isolates. Those viruses showed moderate replication competence and induced robust proinflammatory responses, suggesting potential risk for human health.
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Hui et al. (2026) studied this question.
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