Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo

Yiting Xue; Asad Mustafa Karim; Wan Rong Sia; Fei Han; Kai Lin Chan; Nathalie Grace Chua; Leila Hadadi; Zeyu Liu; Jeffrey Y W Mak; David P. Fairlie; Lu Wang; Johan K Sandberg; Andrea Lay-Hoon Kwa; Edwin Leeansyah

doi:10.1093/infdis/jiag151

March 20, 2026The Journal of Infectious Diseases

Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo

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Key Points

Investigating how restoring MAIT cell function can improve carbapenem effectiveness against resistant bacteria.
Utilized tailored antigen and cytokine stimulation to activate MAIT cells.
Conducted ex vivo experiments to evaluate the effects on carbapenem efficacy.
Analyzed the impact of MAIT cell reinvigoration on antimicrobial resistance.
Restored MAIT cell function significantly enhanced the effectiveness of carbapenem treatment.
Tailored stimulation showed promise in improving outcomes against resistant bacterial infections.
MAIT cell-based strategies indicate potential for adjunct therapies in vulnerable populations.

Implication

Tailored interventions boost carbapenem efficacy in infection contexts, suggesting new treatment strategies.

Abstract

Tailored antigen and cytokine stimulation reinvigorates MAIT cell effector function and augments carbapenem efficacy, supporting MAIT cell-based host-directed adjunct strategies against AMR in vulnerable patients.

Discussion

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Cite This Study

Xue et al. (2026) studied this question.

synapsesocial.com/papers/69d0ae94659487ece0fa48bd https://doi.org/10.1093/infdis/jiag151

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Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo

Key Points

Implication

Abstract

Discussion

Cite This Study

Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo

Key Points

Implication

Abstract

Discussion

Cite This Study

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