Acute responses to NMES show metabolic adaptation in individuals with limited physical activity, suggesting exercise benefits.
A single submaximal NMES-session elicited acute systemic responses characterized by downregulation of key inflammation-related proteins, mild myoglobin elevation and lower glucose levels - changes that mirror patterns observed after moderate exercise. These findings suggest that NMES at well-tolerated submaximal intensities can induce metabolic adaptations and may represent a safe, exercise-mimicking intervention to counteract inflammation and metabolic dysfunction in individuals with limited physical activity.
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Flodin et al. (2026) studied this question.
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