Intricacies in Iron-Sulfur Cluster Function and Biogenesis: Functional Versatility, Sulfur Sources, and Enzyme Specificity

Q: What does this research mean for the field?

Iron-sulfur (Fe-S) clusters expand protein chemistry and biological versatility through constitutive or transient coordination, relying on specific sulfur sources and enzyme specificities for their biogenesis and function. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sarah M. Spigelmyer; Patricia C. Dos Santos

doi:10.1039/d5cb00330j

January 1, 2025RSC Chemical BiologyOpen Access

Intricacies in Iron-Sulfur Cluster Function and Biogenesis: Functional Versatility, Sulfur Sources, and Enzyme Specificity

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Key Points

The purpose is to investigate the functional versatility and biogenesis of iron-sulfur clusters in various biological contexts.
Review of existing literature on iron-sulfur cluster functions and biogenesis.
Analysis of sulfur sources involved in cluster formation.
Discussion of enzyme specificity related to iron-sulfur clusters.
Iron-sulfur clusters exhibit diverse biochemical roles across different organisms.
Different sulfur sources contribute to the biogenesis of these clusters.
Specific enzymes demonstrate varying affinities for iron-sulfur clusters, indicating functional specialization.

Implication

Exploration of iron-sulfur cluster roles in enzyme function, indicating their biochemical significance across life forms.

Abstract

Iron-sulfur (Fe-S) clusters are ancient inorganic cofactors ubiquitous across all domains of life. These cofactors associate with proteins through constitutive or transient coordination, expanding their chemistries and versatility in biological...

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Cite This Study

Spigelmyer et al. (2025) studied this question.

synapsesocial.com/papers/69d0af36659487ece0fa5103 https://doi.org/10.1039/d5cb00330j

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Intricacies in Iron-Sulfur Cluster Function and Biogenesis: Functional Versatility, Sulfur Sources, and Enzyme Specificity

Key Points

Implication

Abstract

Discussion

Cite This Study

Intricacies in Iron-Sulfur Cluster Function and Biogenesis: Functional Versatility, Sulfur Sources, and Enzyme Specificity

Key Points

Implication

Abstract

Discussion

Cite This Study

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