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April 2, 2026Neurology and TherapyOpen Access

Transcutaneous Auricular Vagal Nerve Stimulation Against Fatigue Syndrome in Patients with Long COVID: Results of the Randomized, Placebo-Controlled Clinical Pilot Trial COVIVA

Mortimer Gierthmuehlen Kirsten Schmieder Niklas Thon Petra C. Gierthmuehlen

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Key Points

To evaluate the efficacy of transcutaneous auricular vagal nerve stimulation on fatigue syndrome in long COVID patients.
Conducted a randomized, placebo-controlled clinical trial
Participants diagnosed with long COVID experiencing fatigue were enrolled
Transcutaneous auricular vagal nerve stimulation was administered to one group while the other received a placebo
The intervention group showed improvement in fatigue symptoms
Statistical analysis indicated significant differences between the treatment and placebo groups

Implication

Randomized trial tests auricular nerve stimulation for fatigue syndrome in long COVID patients, suggesting potential benefits.

Discussion

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Cite This Study

Gierthmuehlen et al. (2026) studied this question.

synapsesocial.com/papers/69d0af83659487ece0fa56ec https://doi.org/10.1007/s40120-026-00928-w

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effect of Percutaneous Auricular Nerve Stimulation on Fatigue in Adults with Post-COVID Fatigue (PAuSing-pCF): Results of a Randomised, Sham-Controlled TrialOriginal Research · 2026
2Percutaneous Auricular Nerve Stimulation for Treating Post-COVID Fatigue (PAuSing-pCF): a single-site, single-blind, sham-controlled, randomized, interventional, crossover study protocol2025 · 1 citations
3Transcutaneous Auricular Vagus Nerve Stimulation for Post-COVID-19 Condition: A Systematic Review and Critical Appraisal of Clinical EvidenceSystematic Review · 2026 · 1 citations
4Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Fatigue in Post‐COVID Syndrome: A Randomized, Single‐Blind, Sham‐Controlled StudyRCT · 2025 · 2 citations
5ReVita: home-based transcutaneous auricular vagus nerve stimulation for reducing pathological fatigue in chronic neurological and post-infectious conditions—study protocol for a randomized, double-blind, sham-controlled trialRCT · 2026