What question did this study set out to answer?

To evaluate the utility of biomarkers in the early diagnosis of Alzheimer's disease and related dementias.

April 4, 2026CureusOpen Access

Biomarkers in the Early Detection of Dementia: A Systematic Review

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Systematic review examines biomarkers for early diagnosis of dementia, suggesting significant potential for early intervention.

To evaluate the utility of biomarkers in the early diagnosis of Alzheimer's disease and related dementias.
Systematic review of studies from 2012 to 2025
Focused on biomarkers for early dementia diagnosis
Included observational studies, meta-analyses, and systematic reviews
Utilized PRISMA flow diagram for screening studies
Identified key biomarkers: amyloid beta, total tau, phosphorylated tau, ApoE4
Phosphorylated tau p-tau 217 shows high sensitivity for early AD
Novel biomarkers such as miRNAs and biosensors show potential
Genetic and imaging biomarkers can indicate changes before clinical symptoms occur

Putnam et al. (2026) studied this question.

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