What does this research mean for the field?

Dietary supplementation of beef cows with rumen-inert mono- and polyunsaturated fatty acids and rumen-protected choline during early gestation alters gene expression in placental cotyledons at parturition, particularly in pathways related to inflammation, immunity, and mitochondrial function. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim was to explore how dietary supplementation affects gene expression in placental tissue during early pregnancy in beef cows.

April 4, 2026Journal of Animal Science

Dietary Fatty Acid Profile and Choline Altered the Transcriptome of Placental Tissue in Beef Cows

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Authors

AMAllyson McCartyNorth Carolina State University MBMegan BahrNorth Carolina State University PBPriyanka BanerjeeAuburn University

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Implication

A study shows dietary fat and choline influence gene expression in placentas, suggesting improved fetal development.

Key Points

The aim was to explore how dietary supplementation affects gene expression in placental tissue during early pregnancy in beef cows.
One hundred multiparous Angus cows were assigned to treatments with varying fatty acid and choline sources.
Cows were synchronized and artificially inseminated at day 0 after a 7-day hormone protocol.
Cotyledon tissue was collected at calving for RNA sequencing to analyze gene expression.
Statistical analysis was performed using ANOVA and DESeq2 for differentially expressed genes.
157 differentially expressed genes identified between control and treatment groups, with 40 upregulated and 117 downregulated.
621 differentially expressed genes found in males only, with 270 upregulated and 351 downregulated.
Gene expression changes were linked to pathways modulating inflammation and mitochondrial function.

Cite This Study

McCarty et al. (2026) studied this question.

synapsesocial.com/papers/69d0afc7659487ece0fa5cbc https://doi.org/10.1093/jas/skag057.046

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Dietary Fatty Acid Profile and Choline Altered the Transcriptome of Placental Tissue in Beef Cows

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Key Points

Cite This Study

Dietary Fatty Acid Profile and Choline Altered the Transcriptome of Placental Tissue in Beef Cows

Discussion

Member takes

Implication

Key Points

Cite This Study

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