What question did this study set out to answer?

The study aims to explore how FGF21 affects insulin sensitivity in brown adipose versus skeletal muscle tissues.

April 4, 2026EndocrinologyOpen Access

FGF21 targets pathways which enhance insulin sensitivity in brown adipose, but not skeletal muscle in mice

View Full Paper

Ask AI

Bookmark

Authors

Research demonstrates FGF21 enhances insulin sensitivity in brown adipose tissues, indicating tissue-specific effects.

The study aims to explore how FGF21 affects insulin sensitivity in brown adipose versus skeletal muscle tissues.
Administered FGF21 pharmacologically to mice
Expressed FGF21 co-receptor β-klotho in skeletal muscle
Conducted phospho-proteomics analysis in brown adipocytes
Assessed insulin-stimulated glucose uptake in both tissue types
FGF21 enhances insulin-stimulated glucose uptake specifically in brown adipocytes
Skeletal muscle does not respond to FGF21 regarding insulin sensitivity
FGF21 administration increases phosphorylation of proteins related to GLUT4 trafficking in brown adipocytes

Juber et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark