COVID-19 pandemic-driven evolution of Klebsiella pneumoniae : rising resistance, genetic diversity, and virulence in a Brazilian tertiary hospital

January 1, 2026Einstein (São Paulo)Open Access

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Key Points

The aim is to investigate the evolution of Klebsiella pneumoniae during the COVID-19 pandemic, focusing on resistance and genetic diversity.
Analyzed resistance patterns of Klebsiella pneumoniae isolates during the COVID-19 pandemic
Conducted genomic analyses to assess diversity among blaKPC-positive isolates
Monitored shifts in mobile genetic elements and virulence markers over time
Carbapenem resistance doubled from 2019 to 2020 during the pandemic
High genetic diversity was found among blaKPC-positive isolates with new sequence types emerging
Significant changes in virulence markers and mobile genetic elements were observed, including the rise of ICEKp4.

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Genomic analyses reveal rising resistance and genetic diversity in Klebsiella pneumoniae during COVID-19, suggesting urgent infection control needs.

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Sales et al. (2026) studied this question.

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