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April 4, 2026Analysis & Sensing

Non‐Faradaic Electrochemical Immunosensor for sRAGE Quantification in Rheumatoid Arthritis Using Gold Interdigitated Electrodes

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Authors

GMGeorgeena MathewAPAkkshan PrakashSPSreekaamya Pilaka

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Overview

Non-Faradaic electrochemical biosensor quantifies sRAGE in rheumatoid arthritis, suggesting a new tool for monitoring disease severity.

Key Points

  • This research aims to develop a biosensor for the detection of sRAGE, a biomarker for rheumatoid arthritis severity.
  • Developed a label-free electrochemical impedance spectroscopy biosensor
  • Used gold-modified electrodes functionalized with dithiobis and RAGE-specific antibodies
  • Optimized the sensor with 1 µg/mL antibody and 2 mM DSP
  • Evaluated sensor performance against C-reactive protein
  • Simulated electric field distribution and impedance shifts using COMSOL Multiphysics
  • Achieved a linear detection limit of 17.76 pg/mL for sRAGE
  • Demonstrated a dynamic detection range from 1000 to 6274 pg/mL
  • Confirmed high analytical precision and spike-recovery accuracy
  • Showed susceptibility to interference from C-reactive protein was minimal
  • Simulations aligned with experimental results, enhancing understanding of sensor behavior

Cite This Study

Mathew et al. (2026) studied this question.

synapsesocial.com/papers/69d0aff2659487ece0fa6144https://doi.org/10.1002/anse.202500233
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