What question did this study set out to answer?

To systematically review and analyze the transformation characteristics and prognosis from non-small cell lung cancer (NSCLC) to small-cell lung cancer (SCLC).

April 4, 2026Cancer Research

Systematic Analysis of NSCLC to SCLC Transformation Characteristics

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Authors

DXDuo XuJiamusi University XWXiaomei WuKunming University of Science and Technology BZBo ZhuSecond Affiliated Hospital of Guangzhou Medical University

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Implication

This systematic review identifies clinicopathological characteristics and outcomes of NSCLC transforming to SCLC, suggesting critical management implications.

Key Points

To systematically review and analyze the transformation characteristics and prognosis from non-small cell lung cancer (NSCLC) to small-cell lung cancer (SCLC).
Systematic review of literature from 2015 to present
Data extraction from 72 publications
Analysis of clinicopathological features and prognostic outcomes
Integration of data on treatment strategies pre- and post-transformation
Identified 82 patients transforming from NSCLC to SCLC, primarily male with a median age of 61
EGFR mutation rate was 58.54% pre-transformation; increased to 84.6% post-transformation
Median overall survival post-SCLC diagnosis was 12 months, with significant variations based on demographics and initial disease stage
Median progression-free survival decreased from 12.1 months pre-transformation to 8.0 months post-transformation

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69d0b028659487ece0fa62a0 https://doi.org/10.1158/1538-7445.am2026-855

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Implication

This systematic review identifies clinicopathological characteristics and outcomes of NSCLC transforming to SCLC, suggesting critical management implications.

Systematic Analysis of NSCLC to SCLC Transformation Characteristics

Discussion

Member takes

Implication

Key Points

Cite This Study

Systematic Analysis of NSCLC to SCLC Transformation Characteristics

Discussion

Member takes

Implication

Key Points

Cite This Study

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