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May 1, 1986AJP Regulatory Integrative and Comparative Physiology

Respiratory phase locking during mechanical ventilation in anesthetized human subjects

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Why the study?

How do different frequencies and amplitudes of mechanical ventilation affect spontaneous breathing patterns in anesthetized adults?

Population

enflurane-anesthetized adult human subjects

Design

Other

Authors

CGConstance L. GravesUniversity of OregonLGLeon GlassElectrophysiologyDLD. Laporta

Discussion

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Implication

May warrant attention to ventilator frequency in anesthetized patients; leaves open effects on clinical outcomes.

Structured PICO

How do different frequencies and amplitudes of mechanical ventilation affect spontaneous breathing patterns in anesthetized adults?

P
Population
enflurane-anesthetized adult human subjects
I
Intervention
different frequencies and amplitudes of forced lung inflations (mechanical ventilation)
O
Outcome
coupling patterns between the rhythm of a mechanical ventilator and the rhythm of spontaneous breathingsurrogate

Mechanical ventilation can entrain spontaneous breathing rhythms in anesthetized humans, demonstrating respiratory phase locking dependent on ventilator frequency and amplitude.

Cite This Study

Graves et al. (1986) studied this question.

synapsesocial.com/papers/69d18cca360df9e887456ff3https://doi.org/10.1152/ajpregu.1986.250.5.r902
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Breuer-Hering inflation reflex and breathing pattern in anesthetized humans and cats1981 · 38 citations
  2. 2The importance of timing on the respiratory effects of intermittent carotid sinus nerve stimulation1972 · 83 citations
  3. 3The Effects of Intermittent Positive Pressure Breathing on Intrathoracic Pressure, Pulmonary Mechanics, and the Work of Breathing <sup>1,</sup> <sup>2,</sup> <sup>3</sup>1963 · 48 citations
  4. 4Phasic vagal influence on inspiratory motor output in anesthetized human subjects1980 · 59 citations
  5. 5Phase locking of the respiratory rhythm in cats to a mechanical ventilator1983 · 74 citations