Do low-dose diuretics prevent cardiovascular disease morbidity and mortality better than other first-line antihypertensive therapies?
Low-dose diuretics should be considered the standard first-line antihypertensive therapy for preventing cardiovascular morbidity and mortality.
Low-dose diuretics are the most effective first-line treatment for preventing the occurrence of cardiovascular disease morbidity and mortality. Clinical practice and treatment guidelines should reflect this evidence, and future trials should use low-dose diuretics as the standard for clinically useful comparisons.
Psaty et al. (2003) studied this question.