Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70): Protocol for a hybrid implementation-effectiveness study in three community oncology practices in the United States

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Key Points

Evaluate the implementation of the Practical Geriatric Assessment (PGA) in community oncology practices and its predictive capabilities for chemotherapy-related outcomes.
Hybrid implementation-effectiveness design across three oncology sites
Enrollment of approximately 140 patients in an implementation cohort and up to 100 in a correlative cohort
Utilization of EHR for PGA completion and triggering clinical recommendations
Assessment of correlations between PGA findings and various health outcomes using logistic regression techniques
Increased PGA completion rates are targeted as the primary outcome
Secondary outcomes include enhanced frequency of clinical actions based on PGA guidance
Predicted associations between PGA impairments and chemotherapy toxicity, hospitalizations, falls, and quality of life

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PACE-70 showcases an implementation strategy for PGAs in older cancer patients, suggesting improved clinical care delivery.

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Aleixo et al. (2026) studied this question.

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