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April 5, 2026Cancer Research

SETD4 Role in Cell Proliferation and Methotrexate Sensitivity in Pediatric ALL

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Authors

MLMariana Braccialli de LoyolaAGAna Cristina Moura GualbertoBSBrunna Letícia Olivera Santana

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Overview

Demonstrates SETD4's influence on cell proliferation and methotrexate sensitivity in pediatric acute lymphoblastic leukemia, suggesting its potential as a biomarker.

Key Points

  • To investigate the role of SETD4 in leukemogenesis and its impact on methotrexate response in pediatric acute lymphoblastic leukemia.
  • Analyzed SETD4 expression in 83 Brazilian pediatric ALL patients and compared with BloodSpot data.
  • Utilized TCGA RNA-seq data to stratify patients based on SETD4 levels.
  • Performed cell line experiments to upregulate and downregulate SETD4 using siRNA.
  • SETD4 overexpression correlated with increased cell proliferation and enrichment of pathways related to oncogenesis.
  • Upregulation of SETD4 in low-expressing cell lines increased proliferation significantly at multiple time points.
  • Higher SETD4 levels enhanced sensitivity to methotrexate, while silencing reduced sensitivity.

Cite This Study

Loyola et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc4fa79560c99a0a1effhttps://doi.org/10.1158/1538-7445.am2026-3194
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SETD2 deficiency in chronic myeloid leukemia (CML) contributes to tyrosine kinase inhibitor (TKI) resistance and disease acceleration by enhancing genetic instability and rewiring cellular metabolism and might be a novel biomarker of high risk disease since diagnosis2025
  2. 2Changes in the Expression of DNMTs Before and After Treatment with Methotrexate (MTX)/Mercaptopurine (6-MP) in B-Cell ALL Children2024
  3. 3Abstract PR07: <i>SETD1B</i> mutations confer apoptosis resistance and BCL2 independence in B-cell lymphoma2024
  4. 4Abstract 3122: Integrative multi-omic investigation of gene regulatory networks associated with chemotherapy response in acute lymphoblastic leukemia2026
  5. 5Loss of SETD8 Impairs Mitochondrial Homeostasis to Suppress Leukemia Stem Cell Function in t(8;21) Acute Myeloid Leukemia2025