Abstract 7559: Implementation of an interactive clinical trials education and decision tool for Florida cancer patients at an NCI Center.

Abstract Background: CHOICES Decision Aid (DA) is an evidence-based, interactive, education and decision-making support tool (available in English and Spanish) for cancer patients about participation in cancer clinical trials (CCTs). As part of the ACT WONDERS study, a multi-level intervention aimed at increasing referral and enrollment of diverse patients to CCTs, the website was made accessible to new Moffitt Cancer Center patients residing in seven geographically defined study intervention zones in the catchment area. CHOICES DA features education content such as facts about CCTs, values clarification tools on CCT participation, and patient narratives about CCT participation. Method: Eligible patients were able to access the site via patient portal and received an email with a description and website link. Upon site exit, patients were asked to complete an optional 5-item survey about subjective CCT knowledge (1-7 scale), preparedness to talk with providers about CCTs (1-7), CCT decision readiness (1-7), and usefulness (1-10), and satisfaction with the site (1-10). Mean scores were re-scaled to 100% for comparison. Usage metrics were continuously monitored. Results: In the first year following intervention launch (September 17, 2024 - October 2, 2025), 550 of 2,340 eligible patients (24%) visited CHOICES DA. Of 550 eligible patients who viewed the site, race demographics were: white 37% (n=203); Black 4% (n=27); other race 4% (n=23); not reported 54% (n=297). Ethnicity was 11% (n=61) Hispanic/Latino, 33% (n=181) non-Hispanic/Latino, and 56% (n=308) unknown. Mean age was 65 (range 56-73). 10% of users returned to the site at least once. 13% of patients viewed the Spanish site. 45 (8%) patients completed the survey. Mean self-rated CCT knowledge was 84%, readiness to decide about CCTs was 83%, and readiness to discuss CCTs with a doctor was 88.6%. Mean website usefulness and satisfaction were 86% and 85%, respectively. Conclusion: Findings suggest CHOICES DA could be readily implemented in a high-volume oncology care setting leveraging existing communication channels available to patients. Survey completers gave high ratings to their CCT knowledge and readiness to discuss and make decisions about participation in CCTs, as well as website satisfaction and usefulness. CHOICES DA will also be evaluated at the two-year post-implementation time point, and future analyses will examine the impact on CCT enrollment at the cancer center. Citation Format: Susan T. Vadaparampil, Lindsay N. Fuzzell, Elliott S. Tapia-Kwan, Yayi Zhao, Rossybelle Amorrortu, Dana Rollison, Margaret Byrne, . Implementation of an interactive clinical trials education and decision tool for Florida cancer patients at an NCI Center abstract. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 7559.