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April 5, 2026Cancer Research

The Role of MALT1 in Chronic Lymphocytic Leukemia Development in Eμ-TCL1 Mice

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Authors

DCDelia A. CarlinoJBJulia R. BoehlingTRTerri Rasmussen

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Overview

This research investigates MALT1's role in CLL development using a CRISPR model in mice, suggesting therapeutic implications.

Key Points

  • To determine the requirement of MALT1 in the development of chronic lymphocytic leukemia (CLL) in Eμ-TCL1 mice.
  • Crossbred Eμ-TCL1 mice with CRISPR-mediated MALT1 knockout mice.
  • Established cohorts with varying MALT1 genotypes to evaluate leukemia development.
  • Measured leukemia burden via splenomegaly and analyzed cell populations using flow cytometry.
  • Used Kaplan-Meier method for survival analysis.
  • Lower leukemia burden observed in Eμ-TCL1-/-/MALT1-/- and Eμ-TCL1wt/MALT1-/- cohorts compared to Eμ-TCL1wt/MALT1wt.
  • Significant differences in leukemia burden were noted in bone marrow and peritoneal fluid (p-values = 0.0016, 0.0017, 0.0161, 0.0162).
  • All cohorts exhibited longer survival than Eμ-TCL1wt/MALT1wt; the Eμ-TCL1wt/MALT1+/- cohort had a median survival of 435 days.
  • Complications like dermatological lesions were common in knockout cohorts, highlighting side effects of MALT1 inhibition.

Cite This Study

Carlino et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc8ea79560c99a0a221ehttps://doi.org/10.1158/1538-7445.am2026-7533
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract B046: The GPCR-MALT1 protease signaling axis drives an immunosuppressive secretome in triple-negative breast cancer2026
  2. 2The requirement of MALT1 activity for the growth of adult T cell leukemia/lymphoma2026
  3. 3Longitudinal immune dynamics associated with chronic lymphocytic leukemia development in mice with 13q14 deletion and modulation by early BTK inhibition2025
  4. 4Abstract 7583: Discovery of a potent small molecule MALT1 protease inhibitor for the treatment of cancer2024
  5. 5CD4+ T cells sustain aggressive chronic lymphocytic leukemia in Eμ-TCL1 mice through a CD40L-independent mechanism2021 · 18 citations