Findings demonstrate adaptive changes in sodium handling in claudin-3-deficient mice under low-salt diet, suggesting compensatory mechanisms.
Our findings demonstrate that aldosterone strengthens the paracellular sodium barrier in the collecting duct by inducing claudin-3. In the absence of claudin-3, compensatory regulation of other claudins and sodium transporters preserves sodium homeostasis under low-salt conditions, thus revealing adaptive mechanisms in renal sodium handling.
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Sassi et al. (2026) studied this question.
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